Video of Jed Rose explain those regions of the brain that controls the desire is available in the following format: RealMedia, QuickTime and Windows Media Video.DURHAM, N.C. –--In memory of all smokers try to quit rages say a struggle between the higher-order functions in the brain like to break the habit and lower-order features screaming for another cigarette, researchers at Duke University Medical Center; more often than not, that cigarettes lit.
Brain scans of the researchers showed smokers studied three specific areas deep in the brain that appears to control the dependence on nicotine and craving for cigarettes.These regions are playing important roles in some of the most important reasons for smoking: to calm when stressed, to achieve pleasure and to help concentration.
"If you can't calm down, can not derive pleasure and cannot control yourself, or to concentrate, it becomes extremely difficult to break a habit," said lead study investigator Jed e. Rose, Ph. d., Director of Duke Center for nicotine and non-smoking trailing research. "These regions that the brain can explain why most people try to quit several times before they are successful. "
Knowledge of how the brain responds to cigarette cravings can doctors change nicotine cessation treatments to deal with all three of these components, the right of withdrawal, "says Rose.Medicinal products or therapies that are intended for these regions can help smokers to avert the cravings that often spoil their attempts to quit.
The Group's results are now online in the journal Neuropsychopharmacology. Research was funded by Phillip Morris USA.
Approximately one in five Americans smoke. Despite the fact that 70% of smokers report that they would like to quit, do only 5% it successfully.
Scientists manipulated nicotine dependence and eager amongst 15 smoker and then scanned their brains with positron emission computed tomography of cigarettes or PET scans, to see which areas of the brain were most active in this study.
Three specific regions of the brain showed changes in activity when smokers craved cigarettes versus when they did not do.
A region which comes on, called the Thalamus, considered to be the most important relay sensory information flowing into the brain, some of the symptoms of withdrawal among people who try to quit arise from the inability to focus your thoughts and feeling of being overwhelmed, and thus could be explained by changes in this region, according to scientists, researchers found that changes in this region was the most dramatic among those who said they smoked in order to calm when under stress.
Another region which lights up is part of the pleasure in the brain. Changes in this region, known as the striatum, was most notable in people who smoked comply with Avid and for pleasant relaxation, the researchers said.
A third area that is turned on, is called the anterior cingulate Cortex, very important cognitive functions such as conflict, self-regulation, decision-making and feelings; People whose brain scans showed most differences in this region also reported that they smoked to manage their weight.
"This knowledge gives us new clues about the brain mechanisms underlying addiction of cigarettes and can give us design better methods to help smokers quit," Rose said.
Rose and his colleagues is now planning to carry out the brain scans of smokers undergoing nicotine replacement therapy, such as nicotine patch, to determine how these treatments affect the same regions of the brain.
Posted by: Geethu Source
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